While many individuals can benefit from B12 injections, certain groups may see more significant or rapid improvements: Vegetarians and Vegans Plant-based diets are often low in B12, making supplementation crucial
Lancet 392, 508520
Not for human or veterinary use, and not intended for injection, ingestion, topical application, or cosmetic use
Novel pyoverdine inhibitors mitigate Pseudomonas aeruginosa pathogenesis
In a phase 2, multicenter, randomized, placebo controlled double blind study, crizanlizumab with or without hydroxyurea (SUSTAIN study) (ClinicalTrails.gov Identifier: NCT01895361) showed that patients on the treatment arm had significantly lower rate of sickle-related pain crises compared to placebo with a lower incidence of adverse events - 10% of patients suffered from moderate side effects while one patient suffered from an intracranial bleed during treatment with this drug that could also interfere with platelet function via its effects on selectins ( Post hoc analyses showed that more patients were VOC event-free in the crizanlizumab arm than in the placebo arm, and that crizanlizumab also significantly increased time-to-first VOC compared to the placebo (Kutlar et al., 2019)
It comes in two forms: ubiquinone (the oxidized form) and ubiquinol (the reduced, active form)
