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Regulatory agencies have investigated this concern for GLP-1 agonists as a class

Phase IIb clinical data in Chinese adults with obesity/overweight demonstrated that after 30 weeks of treatment, the mean percentage change in body weight from baseline ranged from -11.15% to -17.78%, compared to -0.99% in the placebo group, highlighting the potential of GZR18 injection in weight loss

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[10] [11] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, constipation, and abdominal discomfort

The clinical evidence is striking