In VISTA, the most common adverse events with elecoglipron (75mg) compared to placebo respectively were nausea (55%, 20%), constipation (41%, 6%), diarrhoea (35%, 25%) and vomiting (29%, 5%)
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While they are both oral medications used to treat type 2 diabetes, they are in different classes of medications
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Research consistently shows that optimizing one agent to its full therapeutic dose outperforms combining multiple agents at low doses
As a general rule, the more tissue that can be obtained, the better the pathologist's interpretation of the tissue abnormalities will be