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Was the model diet-induced obesity

doi:10.1210/endo.142.12.8617 Heffernan MA, Jiang WJ, Thorburn AW, Ng FM

Doctors need to think about these differences when planning treatment

Blood tests help confirm deficiency, monitor the effectiveness of injections, and prevent unnecessary overuse

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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction