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Nishida, M., Yoshida, M., Nishiumi, S., Furuse, M

It notes no clinically relevant effect on gastric emptying rate at the 2.4 mg dose and no clinically relevant interactions with the oral medications tested

After two or more weeks without administration, restarting at the full maintenance dose risks severe gastrointestinal distress because receptor adaptation has partially reversed

This step requires the use of appropriate deprotective agents and acid cutting reagents

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Rationale for GLP-1/Glucagon Combination Therapy for Weight Loss Although significant progress was made in understanding the potential use of the endogenous GLP-1/glucagon co-agonist OXM as a weight loss therapeutic in the early 2000s, evidence from various pre-clinical and human studies prior to this demonstrated the distinct mechanisms of weight loss afforded by these hormones