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The therapeutic efficacy of Mel-HA-MN was evaluated using the rat adjuvant-induced arthritis (AIA) model, where the microneedles penetration ability was tested by applying the patch on the rats abdominal skin ( Results demonstrated that Mel-HA-MN effectively penetrated the skin to a depth of approximately 200 m

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doi: 10.3233/JAD-2010-100717 92 GregoryJ

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