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10.1016/j.ejphar.2014.01.046 [DOI] [PubMed] [Google Scholar] Duzel A., Vlainic J., Antunovic M., Malekinusic D., Vrdoljak B., Samara M., et al

Another study was conducted similarly in both obese and lean mice

[1] Those who cannot digest or absorb B12 as a result of inherited genetics or damage to the stomach and small intestine require more than can be absorbed from sublingual supplementation

This will usually involve lifestyle changes for you

The decreased thiosulfate concentration seems to be associated with formation of a thiosulfate/hydroxocobalamin complex, because hydroxocobalamin can form a complex with thiosulfate

Wang Z et al