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The primary composite endpoint of doubling of serum creatinine concentration, end-stage kidney disease, or death was reduced by 16% in patients under treatment with losartan according to the intention-to-treat analysis (P=0.02), an effect that remained after adjustment for blood pressure

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[13] [14] While this potential benefit is being investigated, it should not be considered a primary reason for using these medications, which are specifically FDA-indicated for weight management and/or glycemic control in appropriate patients