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Back 'The journey to understanding incretin systems: Theory, practice and more theory', Journal of Diabetes Investigation , 10/5
Retatrutide remains an investigational medication
GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]
On the other hand, if you tolerate the once-weekly injection well and are seeing consistent results, there is little reason to switch
Hepatic metabolism research has examined Retatrutides influence on liver fat markers in pre-clinical models of non-alcoholic fatty liver disease, with studies exploring how combined GLP-1, GIP, and glucagon receptor activation affects hepatic lipid handling compared to dual-receptor compounds
38% of GLP-1 users say they may switch to an alternative like Compounded* Liraglutide with B12 soon
