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review at 4 mg, 9 mg, 12 mg Best For Mirrors current Phase 3 maintenance arms Approach Slow titration Duration Add 2-4 weeks per dose step when GI symptoms persist Review Point Each dose step Best For When nausea, vomiting, or diarrhea is hard to tolerate Trial protocols allowed participants to stay at the current dose for an extra 2-4 weeks when GI side effects were significant

The announcement comes as competition in the GLP-1 space continues to increase for Novo Nordisk

Clin Med Insights Endocrinol Diabetes 4:4762 Zhong P et al (2022) Efficacy and safety of once-weekly semaglutide in adults with overweight or obesity: a meta-analysis

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This is especially important for patients on higher doses who have been on therapy for extended periods

Thiazolidinediones: the forgotten diabetes medications