In vitro studies have characterised its binding interactions with nitric oxide-related signalling systems and its effects on extracellular matrix protein expression in cell culture models
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Nevertheless, pharmacological treatment is the first choice of therapy to improve symptoms, using psychostimulants such as methylphenidate (MPH) and amphetamines, which inhibit the reuptake of dopamine and norepinephrine, thus increasing catecholaminergic activity in the prefrontal cortex, striatum, and hippocampus, improving symptoms [6,17]
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