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The day of drug initiation was defined as the index date, and the year preceding the index date was defined as the baseline period
10.1038/ijo.2013.162 181
Also, during STEP 5, a study to assess efficacy of semaglutide with a follow-up of 2 years, there is a post-hoc analysis that demonstrates a better performance in the self-reported Control of Eating Questionnaire(CoEQ) to measure changes in appetite versus placebo, with lower cravings for dairy and starchy foods and less desire for salty and spicy food at short-term (20 weeks) but also as a maintenance therapy at weeks 52 and 104 (178)
It would have been more of a surprise if regulators hadn't approved the drug
A representative Phase 2 escalation schedule looked like this: Lower dose arms were reached with correspondingly fewer steps
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