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Over time with rapid weight loss: facial volume loss (Ozempic face) or loose skin can appear, especially in people with a lower starting BMI

Side Effects of Each Medication Both medications can cause specific side effects, and understanding these side effects can help you make an informed decision: Common Side Effects for Both Nausea (most common, especially when starting) Vomiting Diarrhea Constipation Stomach pain Fatigue Headache Semaglutide-Specific Side Effects Nausea affects about 44% of users initially Side effects typically improve after 4-8 weeks Injection site reactions are rare Tirzepatide-Specific Side Effects Nausea affects about 12-18% of users (lower than Semaglutide) May cause more digestive upset initially Some patients report better tolerance overall Most side effects are temporary and resolve as your body adjusts to the medication

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In 2009, Richard DiMarchi and Matthias H Tschp's team reported that dual agonists targeting GLP-1R/GCGR did better in weight loss compared to GLP-1RA [10]