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Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage

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Taken together, IGF-1 signaling, including prolonged Akt and AS160 phosphorylation, may be a specific signal response to acute RE

Its ability to cross the bloodbrain barrier in laboratory models, combined with a relatively long plasma half-life compared to other small neuropeptides, has contributed to its enduring relevance in neurochemistry research