I can also relate to the chronic illness being a chronic neurological lyme disease survivor
The evidence summary below is per-compound only, drawn from the Phase 3 retatrutide program and the preclinical-plus-analog MOTS-c literature
Eli Lilly completed a 48 week phase 2 trial on a selective amylin agonist, eloralintide
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However, as it communicates with the external environment, it is chronically exposed to digestive/corrosive physiological factors, such as gastric acid and digestive enzymes, while being modulated by dynamic homeostatic systems, including the mucus barrier and gut microbiota
NAM treatment increased mitochondrial NAD + /NADH ratios and improved mitochondrial membrane potential in human primary cells 115