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GI side effects dominate both compounds
Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment
ALCL anaplastic large cell lymphoma, ALK anaplastic lymphoma kinase, AXL tyrosine-protein kinase receptor UFO, c-MET hepatocyte growth factor receptor, EMA European Medicines Agency, FDA US Food and Drug Administration, FLT-3 fms like tyrosine kinase 3, KIT KIT proto-oncogene receptor tyrosine kinase, MTC medullary thyroid cancer, NSCLC non-small cell lung cancer, RCC renal cell carcinoma, RET REarranged during Transfection, ROS1 ROS proto-oncogene 1, TIE-2 tyrosine-protein kinase receptor TIE-2, TKI tyrosine kinase inhibitor, TRKB tyrosine receptor kinase B, VEGF vascular endothelial growth factor, VEGFR vascular endothelial growth factor receptor a ALK -fusion positive and ROS1 -positive NSCLC as detected by an FDA-approved test In this review, we will present an overview of approved and novel promising c-MET-inhibitors, with a focus on their safety profile and tolerability
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In FGF21-deficient mice, insulin resistance worsens, hepatic steatosis progresses, and inflammatory signalling rises, confirming FGF21s endocrine role in metabolic homeostasis
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