Since the drug exploded in popularity as a method for losing weight, there has been global shortages of the medication
However, the lack of drug-like characteristics, such as poor target specificity and selectivity, high toxicity, several off-targets, severe side effects, poor metabolic stability, poor membrane permeability and rapid proteolysis, make this molecule fairly unsuitable candidates for therapeutic applications
Safety, Side Effects, and Monitoring in Teen Patients Common side effects of semaglutide and tirzepatide in adultsnausea, vomiting, constipation, and appetite reductionmay affect teenagers differently due to developmental and nutritional considerations
Sci Rep 8(1):10574 Chauhan N et al (2022) GSK-3 and its inhibitors in Alzheimers disease: a recent update
But beyond metabolic effects, theres growing evidence that these drugs could influence processes that are thought to drive Alzheimer's, such as inflammation, insulin resistance in the brain, and abnormal protein buildup
Ermens AAM, Refsum H, Rupreht J, Spijkers LJM, Guttormsen AB, Lindemans J, Ueland PM, and Abels J (1991)