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The R-isomer is the biologically active form, though most supplements contain a 50/50 racemic mixture

The survey was performed during April and May of 2025

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

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The results revealed that the levels of pro-inflammatory cytokines IL-6, IL-12, and TNF- secreted by cells treated with NP4 were 1.45, 5, and 1.78 times higher than those secreted by cells treated with NP2, respectively, further confirming the activation of macrophages