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Patients with chronic inflammatory arthritissuch as RA or psoriatic arthritissometimes show reduced inflammation within weeks of starting GLP-1 medications, even before major weight loss occurs

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled parallel-group study

However, these do have to be prescribed and administered by a healthcare professional, and are more likely to be given to people who have lifelong conditions affecting their ability to absorb B12 or who are at higher risk of consistent deficiency

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