Pipeline of obesity pharmacotherapies GLP-1 receptor agonists GLP-1 RA increase satiety, reduce food intake and delay gastric emptying whilst they also stimulate insulin release and inhibit glucagon secretion in a glucose-dependent manner (Fig
The most frequently reported AEs were gastrointestinal disorders (61% of subjects), which increased in frequency with longer post-dose fasting periods and thus with higher semaglutide exposure
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The medication is doing its job
If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation
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