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J Chromatogr B BioMed Sci Appl

With certain genetic inefficiencies, glutathione production can be reduced 50% or more, and it is estimated that nearly 1 in 3 people has this genetic variant

38 Further, reduced NADPH levels induced by NADPS results in accelerated degradation of DHFR and impairment of the folate cycle, which delays cancer cell growth

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The failure of these antioxidants to seriously modify the toxicity of the herbicide has been attributed mostly to their inability to cross cell membrane barriers and/or to their rapid clearance from cells [3, 4, 6, 7, 10, 11]