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It is primarily produced by hepatocytes, although minor amounts are also synthesized by monocytes, macrophages, intestinal epithelial cells, and bronchial epithelial cells ( A1ATD is primarily characterized by two clinical conditions resulting from a pathophysiological mechanism that leads to either gain or loss of function defects

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Lett Appl Microbiol 40:378384 Shiloach J, Fass R (2005) Growing E