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Nature 593 , 429434 (2021)

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Sourced from Huberman Lab Ep 170

To conduct this first pharmacological experiment, effective, high doses of the compounds, validated in preclinical models with metabolic alterations 33,34,35,41,42 , were selected

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Because these compounds are naturally occurring peptides with restricted patentability, opportunities for intellectual property protection and industry-sponsored development are limitedposing substantial barriers to the resource-intensive clinical investigations required to confirm therapeutic efficacy and long-term safety