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GLP-1 reduces appetite and slows gastric emptying

Delta-sleep-inducing peptide causes a selective reduction of luteinizing hormone secretion in the rat

The pathophysiology of MASLD is complex and multifactorial, involving hepatic lipid accumulation driven by excess adiposity, systemic inflammation, insulin resistance, and activation of hepatic stellate cells (HSC)-factors that collectively contribute to liver injury and fibrogenesis

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Furthermore, the activation of the GIP receptor also improved glucose metabolism in diet-induced obese mice without changing body weight or fat mass [69]