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Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes
With 5mL bacteriostatic water: Peptide mass: 50mg Bacteriostatic water: 5mL Concentration: 50mg 5mL = 10 mg/mL = 10,000 mcg/mL Peptide per unit (100-unit syringe): 10 mg 100 = 0.1 mg/unit = 100 mcg/unit If research protocol calls for 1000 mcg (1mg) per research unit: 1000 mcg 100 mcg/unit = 10 units on the syringe Total doses per vial at 1mg each: 50,000 mcg 1,000 mcg = 50 research doses Why GHK-Cu is supplied in 50mg vials rather than 10mg vials: because research GHK-Cu protocols typically use larger per-research-unit amounts, and a 10mg vial would only supply a few doses
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Marks points out that at that time the two hormones produced by pancreatic islet A and B cells were regarded as 'biological antagonists rather than subtle collaborators in blood glucose control' (Marks 2018)
