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Importantly, folate supplementation should not be started before excluding B12 deficiency

Living with conditions like Long COVID, ME/CFS, POTS, and MCAS is an exhausting, often invisible struggle

Salmon et al

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You may also experience pain, heaviness, pressure or tightness in the chest, throat or other parts of the body, or unusual sensations, including numbness, tingling and warmth or cold

For long-term benefits, such as improvements in fatigue, cognitive function, and overall well-being, it may take a few weeks to months of regular B12 injections