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Intrahepatic cholestasis most often occurs in diseases involving hepatocellular damage, leakage, or swelling, such as infections (e.g., bacterial cholangiohepatitis, toxoplasmosis, FIP, or other diseases causing inflammation), infiltrative diseases (e.g., lymphoma), metabolic diseases (e.g., hepatic lipidosis), or diseases causing disruption of architecture (e.g., cirrhosis or severe polycystic disease)

In individuals with congenital hyperinsulinism due to inactivating mutations in the genes encoding the beta cell K ATP channels, the GLP-1 receptor antagonist, exendin-(9-39), increases fasting plasma glucose and prevents protein-induced hypoglycemia

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Aim for at least 810 glasses daily, and consider adding fiber gradually rather than spiking intake suddenly, which could worsen gastrointestinal discomfort

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