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retatrutide is an incretin-based triple agonist adding GIP, GLP-1, and glucagon activity

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The article names significant kidney or liver disease, diabetic retinopathy, and active gallbladder disease as needing careful evaluation before starting, on top of the contraindications it lists: personal or family history of medullary thyroid cancer and multiple endocrine neoplasia syndrome type 2

Glucagon-Like Peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat -Cells by a protein kinase A-mediated mechanism