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The overexpression of p53, SAT1, ALOX15 proteins, and iron accumulation may lead to ferroptosis in cells, and higher expression levels of p53, SAT1, and ALOX15 proteins could be associated with more severe muscle inflammatory lesions and increased muscle damage [229]

The A4 study: Stopping AD before symptoms begin

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Prediabetes was modestly associated with risk of any complication (HR 1.21 [95% CI 1.15, 1.27]) vs normoglycaemia