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[55] suggested that due to its ability to activate Nrf2, induce antioxidant enzymes, reduce pro-inflammatory cytokines, and its efficacy and safety, SFN is a promising candidate to counteract inflammatory reaction and protect lungs from severe damage during SARS COV 2 infection

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Initially discovered in the context of autoinflammatory syndromes, the NLRP3 inflammasome has now been recognized as a central mediator of sterile inflammation in NDDs

Later, we assessed the correlation between these 9 model genes and significantly infiltrated immune cells and found these genes were markedly correlated with CD8 + T cells and M0 macrophages (Fig