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As for long-term use, these medications are generally well-tolerated for extended periods

The following is the retatrutide dosage schedule used in Phase 3 trials for participants who reached the maximum dose

According to FAIR Health, prescriptions for GLP-1 drugs to treat overweight or obesity rose 587% from 2019 to 2024

Second, if you are still in the titration phase (the first 16-20 weeks), your dose may not yet be high enough to produce significant weight loss