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Another LRRK2 inhibitor NEU-411 is currently investigated in a phase 2 trial (NEULARK, NCT06680830, see Table 5) 5.3 Targeting -Synuclein Pathology Based on the robust evidence for a central role of intraneuronal misfolding, oligomerization and aggregation of -synuclein as well as cell-to-cell transmission of pathological -synuclein species these mechanisms have become key targets for drug development programmes focused on disease modification in PD

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Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts

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650 nm filter) using or excluding a gel of kojic acid, a transethosome encapsulating ferrous chlorophyllin (Fe-CHL), a lipid-based NP, caused a progressive reduction in the size of the tumor in a melanoma mouse model, which totally regressed under one month [268]

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