glp 1 new indications How R&D Is expanding drug across obesity, oncology and cell therapy The GLP‑1 treatment landscape has

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DOI: Published online: July 1, 2025 Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Corresponding author: Hye Jin Yoo Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea E-mail: [email protected] Copyright 2025 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

Upon the accumulation of misfolded proteins in the ER, the XBP1 mRNA undergoes specific splicing, generating the spliced XBP1 transcription factor (sXBP1), which subsequently translocates to the nucleus and drives the expression of stress-induced inflammatory genes

What the Trials Show Beyond average losses, responder analyses from the same obesity RCT showed that 2540 % of participants hit the clinically significant 5 % weight-loss mark at 24 weeks (Obesity 2002)

The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress