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After 28 days, two things have happened

Vitamin B6 may interact with certain medications, including some chemotherapy drugs (e.g., altretamine), sedatives (barbiturates), seizure medications (fosphenytoin, phenytoin), and levodopa for Parkinsons disease

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Feeling nothing is the correct response at these doses

However, here is why you might want to skip the psyllium husk if you are on a weight-loss medication: Delayed Gastric Emptying: Medications like Ozempic, Wegovy, Mounjaro, Zepbound and Retatrutide intentionally slow down your digestive tract