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Developer: Eli Lilly and Company | Administration in Trials: Once-weekly subcutaneous injection First successful Phase 3 trial (TRIUMPH-4, topline Dec 2025): Up to 28.7% average body weight loss at 68 weeks (highest dose) in adults with obesity/overweight and knee osteoarthritis

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Most do not find differences in sweet taste perception between individuals with and without obesity

Although a causal association with acute pancreatitis remains debated, observational studies suggest a higher incidence compared with placebo (Nieto et al., 2025

Because resM uses heat-inactivated bacteria (postbiotics) rather than live probiotic strains, it does not require refrigeration