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GEP44 interacts with GLP-1, Y1, and Y2 receptors to regulate insulin secretion in both rat and human pancreatic islets, and it promotes insulin-independent Y1-R-mediated glucose uptake in rat muscle tissue ex vivo

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36 Liraglutide seems to offer a body-weight loss of 46 kg compared to placebo, 37 while the protective effect on cardiovascular outcomes (lower rates of myocardial infarction, stroke and death) is notable, 38 as is the lower rates of diabetes nephropathy development and progression

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