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According to the SmPC, the following symptoms are frequently observed: Nausea (reported in 1520% of patients) Vomiting Diarrhoea Constipation Abdominal pain and discomfort Bloating and flatulence These effects typically occur during the initial weeks of treatment or following dose escalation, and often diminish over time as the body adjusts to the medication

Therefore, monitoring it as a marker of specific conditions and dynamic changes in its concentration but also in some systems of which it is a part has a significant value

Accommodation in Paracas

Several key mechanisms cause this drop: NAD+-consuming enzymes like CD38 and PARPs become more active with age [6]

Moreira-Pinto B, Costa L, Felgueira E, Fonseca BM, Rebelo I

This demonstrates the importance of treatment simplification and de-intensification among older adults not only to reduce hypoglycemia but also to improve quality of life and attain safe glycemic targets appropriate for patient age