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The TCA cycle orchestrates metabolic plasticity through citrate-mediated lipogenesis and -ketoglutarate (KG)-derived glutamate synthesis via glutamate dehydrogenase, contributing to amino acid metabolism [15]

The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

doi: 10.1038/s41467-024-54367-y 50 LaiSKangZSunJWangZXuYXingSet al

J Animal Sci Biotechnol 16 , 54 (2025)

Patient concerns about sermorelin side effects cancer risks frequency arise during consultations

Increasing the dose might work but adds risk