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Three compounds showed an IC 50 equal to or lower than 62 nM, 72 74 , demonstrating satisfactory activity, and even more so for the most potent amide, with an IC 50 of 28 nM

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doi: 10.1016/j.cgh.2016.09.007 75 SabateM.IbanezL.PerezE.VidalX.ButiM.XiolX.et al