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The research by He et al

For deeper melasma: modified Jessners, TCA spot peels or combination protocols with melasma-specific pre-conditioning

Oral supplements cannot deliver intact peptides

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After disintegration, the so-obtained cell extract (homogenate) was centrifuged (11000 g , 5 min, 4 C), and the liquid was transferred to new test tubes and were frozen and stored at 80 C for biochemical analyses

Iwai T, Ito S, Tanimitsu K, Udagawa S, Oka J