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Management strategies include eating smaller meals, avoiding late-evening eating, limiting reflux triggers like caffeine and spicy foods, elevating the head of the bed, and using over-the-counter antacids or H2-blockers

OTA impairs the antioxidant defense of the cells making them more susceptible to oxidative damage [62] and a reduction in cellular antioxidant defense may contribute to the production of OTA-dependent oxidative damage [76]

Microdosing, however, seeks and maintains the lowest effective dose

placebo on vascular inflammation in 102 patients with T2D over 26 weeks as assessed by fluorodeoxyglucose-positron emission tomography/computed tomography (primary outcome), and also to evaluate endothelial function, coronary artery calcium, and carotid-intima thickness (56)