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INFOGRAPHIC BRIEFS Infographic Brief 1 Placement: After ## How GHK-Cu Is Thought to Work Title: GHK-Cu Mechanism and Skin Biology Pathways Purpose: Explain how GHK-Cu is discussed in relation to copper binding, fibroblast activity, collagen synthesis, extracellular matrix remodeling, inflammation, and wound repair mechanisms

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High-throughput screening methods are used to identify the vast network of genes regulated by GHK-Cu in various cell types, providing a foundation for understanding its broad physiological influence in experimental settings

[PubMed] [Google Scholar] Rinna A, Forman HJ

Nano-Lipid Carrier Delivery Badenhorst et al., Journal of Cosmetic Dermatology (2016) Badenhorst and colleagues evaluated GHK-Cu encapsulated in nano-lipid carrier (NLC) formulations against control serum in a controlled clinical trial measuring facial wrinkle volume and depth

For topical skincare, timing is a minor factor