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Activation of GLP-1R also increases intracellular Ca 2+ through Ca 2+ release from the endoplasmic reticulum (ER) via the inositol 1,4,5 triphosphate receptors activated by PKA and the ryanodine receptors activated by Epac2 (9)

The long-term use of particular medications probably increases the risk of more serious complications

Cesare Patrone, Karolinska Institutet (KI), Sweden Updates Copyright 2020 Kim, Kim and Song

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