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MTF1 mitigates metal toxicity through the expression of the metal-chelating metallothioneins, metal membrane transporters, and antioxidant selenoproteins (Gnther et al, 2012)

doi: 10.1038/s41467-020-18764-3 208 OlejnikJ.HumeA

(PubMed) Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, et al

GSH deficiency can interfere with the body's ability to detoxify the cellular microenvironment, fold proteins, replenish antioxidants, maintain healthy immune responses and even modulate apoptotic events, promoting suboptimal cellular function and development of diseases [53]

It performs best as an adjunct, not a replacement

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