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Ellagic Acid Exerts Beneficial Effects on Hyperuricemia by Inhibiting Xanthine Oxidase and NLRP3 Inflammasome Activation

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The technical pathway: GLP-1 receptors which nobody expected to find on cartilage cells activate the AMPK-PFKFB3 signalling cascade, shifting the cells from glycolysis to oxidative phosphorylation [28]

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Unlike traditional peptide-based agonists that target the extracellular domain, this binding induces a conformational change that triggers potent signaling