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Luchsinger JA

At week 56 the primary HbA1c endpoint was missing for 7%, 5% and 6% of patients and during the trial rescue medication was initiated by 5%, 2% and 19% of patients randomized to OZEMPIC 0.5 mg, OZEMPIC 1 mg and sitagliptin, respectively

Additional non-oral contraception is advised for 4 weeks after starting treatment and for 4 weeks after each dose increase If pancreatitis is suspected (severe, persistent abdominal pain with or without vomiting), stop Mounjaro immediately and seek urgent medical assessment Mounjaro is not indicated for type 1 diabetes or diabetic ketoacidosis The medication is not recommended during pregnancy or breastfeeding Patients should report any suspected side effects via the MHRA Yellow Card Scheme

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However, it is important to keep in mind that this is a rapidly developing field, with many other studies in the pipeline, especially for the newer agents (i.e., GLP-1 receptor agonists)