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Given the pivotal role of oxidative stress in the pathogenesis of MASLD, it is essential to investigate the consequent alterations in the antioxidant defense system, particularly during the heightened production of ROS/RNS throughout the progression of the disease

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Notably, further studies discovered an inducible GPX4 transcript-variant (iGPX4) in NAFLD conditions, and suppression of iGPX4 by siRNA-iGPX4 significantly alleviated oxidative stress and cellular damage by impairing ferroptosis

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