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Perturbations in the resulting lists were grouped into 11 classes: Biotic stress (Bs), Chemicals (Che), Germination (Ge), Light (Li), N-starvation (-N), Fe-deficiency (-Fe), Salt stress (Sa), Hypoxia (Hy), Drought (Dr), Heat (He), and Cold (Co)

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Coming on the heels of the Hims & Hers confrontation and the September 2025 cease-and-desist campaign, these letters establish a clear trajectory: the FDA intends to use the full range of its enforcement authority to curtail what it views as misleading marketing of compounded drugs that circumvent the approval process

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