Specifically, PPAR activation reduces LPS-induced IL-1 production (Subramaniam and Federoff, 2017), whereas rosiglitazone-mediated PPAR activation decreases TNF- secretion (Pisanu et al., 2014)
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Further transcriptomic analysis revealed that PS-NPs exposure significantly downregulated signaling pathways associated with neurodegenerative diseases, with the Parkinson's disease (PD) pathway being the most notably affected (32)
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In addition, the UBX7-p97-UFD1/NPL4 complex, consisting of a ubiquitin-targeted ATP-dependent segregase, p97, and two heterodimeric cofactors, UBX7 and UFD1/NPL4, extracts ubiquitinated NRF2 from the KEAP1-NRF2 complex and transfers it to the 26S proteasome for its degradation [154] (Fig
