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In a 72-week study enrolling 3,172 overweight adults, the highest dose of orforglipron (36 mg) caused 12.4% weight loss

However, the medication's gastrointestinal effects like diarrhea and constipation may indirectly contribute to conditions such as hemorrhoids or anal fissures that cause rectal bleeding

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Boosts Fat Metabolism: L-carnitine helps convert stored body fat into energy by facilitating the transport of fatty acids into the mitochondria